MK-3697
Axon 3805
CAS:
1224846-01-8
Purity:
99%
- Soluble in DMSO
- MF: C23H21N5O3S
- MW: 447.51
Description
MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin receptor antagonist with Ki = 0.95 nM.
More Information
| Parent CAS No. | 1224846-01-8 |
|---|---|
| Chemical Name | N-((5,6-dimethoxypyridin-2-yl)methyl)-5'-methyl-5-(thiazol-2-yl)-2,3'-bipyridine-4-carboxamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1N=CC(C2C=C(C(NCC3N=C(OC)C(OC)=CC=3)=O)C(C3=NC=CS3)=CN=2)=CC=1C |
| MFCD | N.A. |
| InChi | InChI=1S/C23H21N5O3S/c1-14-8-15(11-24-10-14)19-9-17(18(13-26-19)23-25-6-7-32-23)21(29)27-12-16-4-5-20(30-2)22(28-16)31-3/h4-11,13H,12H2,1-3H3,(H,27,29) |
| InChiKey | VSOUDUXMPUHJEU-UHFFFAOYSA-N |
| CID | 46190695 |
| Short Description | Orexin receptor antagonist |
References
- AJ Roecker et al. Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia. Bioorg Med Chem Lett. 2014 Oct 15;24(20):4884-90.
- H Nagase et al. Design and Synthesis of Potent and Highly Selective Orexin 1 Receptor Antagonists with a Morphinan Skeleton and Their Pharmacologies. J Med Chem. 2017 Feb 9;60(3):1018-1040.
- Q Li et al. Molecular modeling technology studies of novel pyrazoylethylbenzamide derivatives as selective orexin receptor 1 antagonists. J Taiwan Inst. Chem. Eng. July 2019, 100, 1-17.
Other Categories
Get a Quote for
Loading...