Neurotensin (NT)

Neurotensin (NT or NTS) is a 13 aminio acid peptide that functions as both a neurotransmitter and a hormone through the activation of the three neurotensin receptors known to date (NT1, NT2, and NT3, GPCR-A7 subfamily). NTS shows a wide range of biological activities.  In the brain, NTS modulates opioid-independent analgesia, the inhibition of food intake and the activity of dopaminergic systems. Consequently, it plays an important role in Parkinson’s disease and the pathogenesis of schizophrenia, the modulation of dopamine neurotransmission, hypothermia, antinociception, and in promoting the growth of cancer cells[1].


[1] Structure of the agonist-bound neurotensin receptor. Jim F. White et al. Nature 2012, 490, 508-513

 

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Axon ID Name Description From price
1975 Dilept Neurotensin and dopamine receptor antagonist €120.00
2632 ML314 Brain penetrant nonpeptidic β-Arrestin biased agonist of NTR1 €95.00
1255 SR 142948 Neurotensin antagonist €125.00
1164 SR 48692 Neurotensin 1 antagonist €85.00

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