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Dilept
- GZR 123
Axon 1975
CAS:
200954-39-8
- Optical Purity: Optically pure
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C21H30N2O5
- MW: 390.47
Description
Neurotensin (NT) and dopamine (DA) receptor antagonist; dipeptide neuroleptic of potential efficacy in relieving positive and negative symptoms of schizophrenia
More Information
| Parent CAS No. | 200954-39-8 |
|---|---|
| Chemical Name | (S)-methyl 2-((S)-1-hexanoylpyrrolidine-2-carboxamido)-3-(4-hydroxyphenyl)propanoate |
| SMILES | C(OC)(=O)[C@H](CC1C=CC(O)=CC=1)NC(=O)[C@@H]1CCCN1C(=O)CCCCC |&1:4,16,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C21H30N2O5/c1-3-4-5-8-19(25)23-13-6-7-18(23)20(26)22-17(21(27)28-2)14-15-9-11-16(24)12-10-15/h9-12,17-18,24H,3-8,13-14H2,1-2H3,(H,22,26)/t17-,18-/m0/s1 |
| InChiKey | HNWPAYLOEFDTJN-ROUUACIJSA-N |
| CID | 9821787 |
| Short Description | NT- and DA antagonist |
References
- MV Retyunskaya et al. Neuromodulatory mechanism underlying the effect of the atypical dipeptide neuroleptic dilept. Bull. Exp. Biol Med. 2003, 136(5), 467-470.
- RU Ostrovskaia et al. Dilept: a tripeptoid neurotensin analog combining neuroleptic activity with positive mnemotropic action. Eksp. Klin. Farmakol. 2005, 68(1), 3-6.
- RU Ostrovskaia et al. Neurotensine dipeptide analog dilept decreases the deficiency of prestimulus startle reflex inhibition: a prognostic sign of antipsychotic activity. Eksp. Klin. Farmakol. 2009, 72(5), 3-7.
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