GLP-1

GLP-1

The Secretin family is a small family of 15 GPCRs (GPCR-B1) that all have an extracellular hormone-binding domain and bind peptide hormones. The members of this family are the calcitonin and calcitonin-like receptors (CALCR, CALCRL); the corticotropin-releasing hormone receptors (CRHR1, CRHR2); the glucagon receptor (GCGR); the gastric inhibitory polypeptide receptor (GIPR); the glucagon-like peptide receptors (GLP1R, GLP2R); the growth-hormone-releasing hormone receptor (GHRHR); the adenylate cyclase activating polypeptide receptor (PAC1/ADCYAP1R1); the parathyroid hormone receptors (PTHR1, PTHR2); the secretin receptor (SCTR); and the vasoactive intestinal peptide receptors (VIPR1, VIPR2). GLP1R and GLP2R are particularly interesting because of their role in appetite regulation and in the treatment of type 2 diabetes.

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  • GLP-1 antagonist
    1132
    GLP-1 antagonist
    The price depends on the options chosen on the product page

    From $165.00

  • GLP-1R agonist DMB
    1907
    GLP-1R agonist DMB
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    From $108.90

  • BETP
    2259
    BETP
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    From $115.50

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More About GLP-1

The Secretin family is a small family of 15 GPCRs (GPCR-B1) that all have an extracellular hormone-binding domain and bind peptide hormones. The members of this family are the calcitonin and calcitonin-like receptors (CALCR, CALCRL); the corticotropin-releasing hormone receptors (CRHR1, CRHR2); the glucagon receptor (GCGR); the gastric inhibitory polypeptide receptor (GIPR); the glucagon-like peptide receptors (GLP1R, GLP2R); the growth-hormone-releasing hormone receptor (GHRHR); the adenylate cyclase activating polypeptide receptor (PAC1/ADCYAP1R1); the parathyroid hormone receptors (PTHR1, PTHR2); the secretin receptor (SCTR); and the vasoactive intestinal peptide receptors (VIPR1, VIPR2). GLP1R and GLP2R are particularly interesting because of their role in appetite regulation and in the treatment of type 2 diabetes[1].

[1] Structural diversity of G protein-coupled receptors and significance for drug discovery. M.C. Lagerström, H.B. Schiöth. Nature Reviews Drug Discovery 2008, 7, 339-357.

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