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PD0220245

Axon 1501
  • Parent CAS:  239094-97-4
Purity:  99%
  • Soluble in water and DMSO
  • MF:  C24H26Cl2N4S2.2HCl
  • MW:  578.45

Description

PD0220245 is a potent, non-peptide antagonist of the interleukin-8 receptors CXCR1 and CXCR2. It blocks chemokine-driven receptor signaling and inhibits functional responses to IL-8/CXCL8, including neutrophil activation and migration.

Dual CXCR1/CXCR2 inhibition makes PD0220245 useful for dissecting chemokine control of inflammatory-cell recruitment. It can be applied in models of neutrophilic inflammation, pulmonary disease and tumor-associated chemokine signaling.

Key Features

  • Potent non-peptide CXCR1/CXCR2 antagonist
  • Blocks IL-8/CXCL8 receptor signaling
  • Inhibits neutrophil chemotaxis and activation responses
  • Useful for studying chemokine-driven inflammatory recruitment

Applications

  • CXCR1 and CXCR2 receptor pharmacology
  • IL-8/CXCL8 signaling studies
  • Neutrophil migration and inflammatory disease models
  • Tumor microenvironment and chemokine-axis research

More Information

Parent CAS No. 239094-97-4
Chemical Name N-(3-[2,20]bithiophenyl-5-yl-6,7-dichloroquinoxalin-2-yl)-N,N-diethyl-butane-1,4-diamine.dihydrochloride
SMILES C1(Cl)C=C2N=C(C3=CC=C(C4SC=CC=4)S3)C(NCCCCN(CC)CC)=NC2=CC=1Cl.Cl.Cl
MFCD MFCD17392567
InChi InChI=1S/C24H26Cl2N4S2.2ClH/c1-3-30(4-2)12-6-5-11-27-24-23(22-10-9-21(32-22)20-8-7-13-31-20)28-18-14-16(25)17(26)15-19(18)29-24;;/h7-10,13-15H,3-6,11-12H2,1-2H3,(H,27,29);2*1H
InChiKey IBVKFSQIGWJQTN-UHFFFAOYSA-N
CID 91826468
Short Description IL-8 antagonist

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