IL-8

CXC chemokine receptors are integral membrane proteins (GPCR-A2) that specifically bind and respond to cytokines of the CXC chemokine family. CXCR1 and CXCR2 (IL8R-α and IL8R–β respectively) are closely related receptors that recognize CXC chemokines that possess an E-L-R amino acid motif immediately adjacent to their CXC motif; they are both expressed on the surface of neutrophils in mammals. While CXCR3 is expressed predominantly on T lymphocytes, the CXCR4 receptor has a wide cellular distribution, with expression on most immature and mature hematopoietic cell types[1].


[1] Chemokine receptors and their role in inflammation and infectious diseases. Murdoch C., Finn A. Blood 2000, 95, 3032–3043

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1501 PD 0220245 IL-8 antagonist €120.00

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