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Aprepitant

Axon 1486
CAS:  170729-80-3
  • Optical Purity:  Optically pure
  • Soluble in DMSO
  • MF:  C23H21F7N4O3
  • MW:  534.43

Description

Aprepitant is a high-affinity antagonist of the neurokinin 1 (NK1/TACR1) receptor. It prevents substance P from activating NK1-dependent G-protein signaling and downstream neuronal and inflammatory responses.

Aprepitant is clinically established as an antiemetic and is also a valuable reference compound for investigating tachykinin signaling, emetic circuitry, nociception and neuroimmune communication.

Key Features

  • High-affinity NK1 (TACR1) receptor antagonist
  • Blocks substance P-mediated receptor activation
  • Suppresses NK1-dependent neuronal signaling
  • Clinically validated antiemetic pharmacology

Applications

  • NK1 receptor and substance P pharmacology
  • Emesis and antiemetic mechanism studies
  • Tachykinin signaling research
  • Neuroinflammation and nociceptive pathway models

More Information

Certificate of Analysis (B2)
Material Safety Data Sheet (B2)

Certificate of Analysis

B1

Material Safety Data Sheet

B1
Parent CAS No. 170729-80-3
Chemical Name 5-[(2R,3S)-2-[(R)-1-(3,5-Bis-trifluoromethyl-phenyl)-ethoxy]-3-(4-fluoro-phenyl)-morpholin-4-ylmethyl]-2,4-dihydro-[1,2,4]triazol-3-one
SMILES C1C(F)=CC=C([C@H]2[C@@H](O[C@H](C)C3C=C(C(F)(F)F)C=C(C(F)(F)F)C=3)OCCN2CC2=NNC(=O)N2)C=1 |&1:6,7,9,r|
MFCD N.A.
InChi InChI=1S/C23H21F7N4O3/c1-12(14-8-15(22(25,26)27)10-16(9-14)23(28,29)30)37-20-19(13-2-4-17(24)5-3-13)34(6-7-36-20)11-18-31-21(35)33-32-18/h2-5,8-10,12,19-20H,6-7,11H2,1H3,(H2,31,32,33,35)/t12-,19+,20-/m1/s1
InChiKey ATALOFNDEOCMKK-OITMNORJSA-N
CID 135413536
Short Description NK1 antagonist

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