Bulk Inquiry
Osanetant
- SR 142801
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C35H41Cl2N3O2
- MW: 606.62
Description
Osanetant (SR142801) is a potent, orally bioavailable, and brain-penetrant neurokinin 3 (NK3) receptor antagonist. It blocks NK3 receptor-mediated signal transduction and is used to study neurokinin signaling biology.
As a selective non-peptide NK3 antagonist, Osanetant is a useful research compound for studies involving NK3R pharmacology, central nervous system signaling, vasomotor symptoms, and addiction-related models.
Key Features
- Potent NK3 receptor antagonist
- Also known as SR142801
- Orally bioavailable and brain-penetrant
- Blocks NK3 receptor-mediated signaling
Applications
- NK3 and neurokinin receptor research
- CNS signaling studies
- NK3R pharmacology
- Vasomotor symptom research
- Addiction-related research models
More Information
| Parent CAS No. | 160492-56-8 |
|---|---|
| Chemical Name | N-(1-{3-[(R)-1-Benzoyl-3-(3,4-dichloro-phenyl)-piperidin-3-yl]-propyl}-4-phenyl-piperidin-4-yl)-N-methyl-acetamide |
| SMILES | N1(CCC[C@@]2(C3C=C(Cl)C(Cl)=CC=3)CN(C(=O)C3C=CC=CC=3)CCC2)CCC(N(C)C(C)=O)(C2C=CC=CC=2)CC1 |&1:4,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C35H41Cl2N3O2/c1-27(41)38(2)35(29-13-7-4-8-14-29)19-23-39(24-20-35)21-9-17-34(30-15-16-31(36)32(37)25-30)18-10-22-40(26-34)33(42)28-11-5-3-6-12-28/h3-8,11-16,25H,9-10,17-24,26H2,1-2H3/t34-/m0/s1 |
| InChiKey | DZOJBGLFWINFBF-UMSFTDKQSA-N |
| CID | 219077 |
| Short Description | NK3 antagonist |
References
- X Emonds-Alt et al. SR 142801, the first potent non-peptide antagonist of the tachykinin NK3 receptor. Life Sci. 1995, 56(1), PL27-32.
- F Kamali. Osanetant Sanofi-Synthélabo. Curr. Opin. Invest. Drugs. 2001, 2(7), 950-956.
- L Quartara and M Altamura. Tachykinin receptors antagonists: from research to clinic. Curr. Drug Targets. 2006, 7(8), 975-992.
- MA De Souza Silva et al. The tachykinin NK3 receptor antagonist SR142801 blocks the behavioral effects of cocaine in marmoset monkeys. Eur. J. Pharmacol. 2006, 536(3), 269-278.
- G Jocham et al. Neurokinin receptor antagonism attenuates cocaine's behavioural activating effects yet potentiates its dopamine-enhancing action in the nucleus accumbens core. Eur. J. Neurosci. 2006, 24(6), 1721-1732.
- List of publications using Osanetant (Axon 1533) purchased from Axon Medchem
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1119 | GR 159897 |
From $143.00 |
| 1486 | Aprepitant |
From $88.00 |
| 1618 | Orvepitant maleate |
From $126.50 |
| 1901 | Casopitant mesylate |
From $137.50 |
| 2499 | Netupitant |
From $154.00 |
| 3138 | Lopinavir |
From $88.00 |
| 3403 | Fezolinetant |
From $154.00 |
