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SCH 79797 dihydrochloride
- Parent CAS: 245520-69-8
- Soluble in DMSO and EtOH
- MF: C23H25N5.2HCl
- MW: 444.4
Description
SCH 79797 dihydrochloride is a potent and selective non-peptide protease-activated receptor 1 (PAR1) antagonist with an IC50 value of 70 nM.
PAR1 is activated by thrombin and regulates platelet activation, endothelial signaling, inflammation, apoptosis and fibrosis-related pathways. SCH 79797 is useful for blocking thrombin-PAR1 signaling in vascular and inflammatory models.
Key Features
- Potent non-peptide PAR1 antagonist
- Blocks thrombin receptor signaling
- Relevant to platelet and vascular inflammation pathways
- Useful for protease-activated receptor pharmacology
Applications
- PAR1 functional assays
- Thrombin signaling studies
- Platelet activation research
- Inflammation, fibrosis and vascular response models
More Information
| Parent CAS No. | 245520-69-8 |
|---|---|
| Chemical Name | N*3*-Cyclopropyl-7-(4-isopropyl-benzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride |
| SMILES | C1CC1NC1=NC2C(C(N)=N1)=C1C=CN(CC3C=CC(C(C)C)=CC=3)C1=CC=2.Cl.Cl |
| MFCD | MFCD04039788 |
| InChi | InChI=1S/C23H25N5.2ClH/c1-14(2)16-5-3-15(4-6-16)13-28-12-11-18-20(28)10-9-19-21(18)22(24)27-23(26-19)25-17-7-8-17;;/h3-6,9-12,14,17H,7-8,13H2,1-2H3,(H3,24,25,26,27);2*1H |
| InChiKey | NNJTXSQXGHYXAJ-UHFFFAOYSA-N |
| CID | 45073452 |
| Short Description | PAR1 antagonist |
References
- JI Strande et al. SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts. Bas. Res. Cardiol. 2007, 102(4), 350.
- C di Serio et al. Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces apoptosis by a protease-activated receptor 1-independent mechanism. Bas. Clin. Pharmacol. Toxicol. 2007, 101(1), 63-69.
- E Sokolova and G Reiser. A novel therapeutic target in various lung diseases: Airway proteases and protease-activated receptors. Pharmacol. Ther. 2007, 115(1), 70-83.
- P Zania et al. Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis. J. Pharm. Exp. Ther. 2006, 318(1), 246.
- HS Ahn et al. Inhibition of cellular action of thrombin by N3-cyclopropyl-7-{[4-(1-methylethyl)phenyl]methyl}-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. Biochem. Pharmacol. 2000, 60(10), 1425-1434.
- List of publications utilizing SCH 79797 dihydrochloride (Axon 1275) purchased from Axon Medchem
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