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SCH 530348
- Vorapaxar - MK 5348
Axon 1755
CAS:
618385-01-6
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C29H33FN2O4
- MW: 492.58
Description
Potent and orally active thrombin receptor (or protease-activated receptor 1, PAR-1) antagonist (Ki value 8.1 nM) that inhibits thrombin-induced platelet activation.
More Information
| Parent CAS No. | 618385-01-6 |
|---|---|
| Chemical Name | ethyl (1R,3aR,4aR,6R,8aR,9S,9aS)-9-((E)-2-(5-(3-fluorophenyl)pyridin-2-yl)vinyl)-1-methyl-3-oxododecahydronaphtho[2,3-c]furan-6-ylcarbamate |
| SMILES | [C@]12([H])C[C@@]3([H])C(=O)O[C@H](C)[C@@]3([H])[C@@H](/C=C/C3N=CC(C4C=C(F)C=CC=4)=CC=3)[C@]1([H])CC[C@@H](NC(=O)OCC)C2 |&1:0,3,8,10,12,28,32,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C29H33FN2O4/c1-3-35-29(34)32-23-10-11-24-20(14-23)15-26-27(17(2)36-28(26)33)25(24)12-9-22-8-7-19(16-31-22)18-5-4-6-21(30)13-18/h4-9,12-13,16-17,20,23-27H,3,10-11,14-15H2,1-2H3,(H,32,34)/b12-9+/t17-,20+,23-,24-,25+,26-,27+/m1/s1 |
| InChiKey | ZBGXUVOIWDMMJE-QHNZEKIYSA-N |
| CID | 10077130 |
| Short Description | PAR1 antagonist |
References
- S Chackalamannil et al. Discovery of a Novel, Orally Active Himbacine-Based Thrombin Receptor Antagonist (SCH 530348) with Potent Antiplatelet Activity. J. Med. Chem. 2008, 51(11), 3061–3064.
- J Oestreich. SCH-530348, a thrombin receptor (PAR-1) antagonist for the prevention and treatment of atherothrombosis. Curr. Opin. Investig. Drugs. 2009, 10(9), 988-996.
- L Aerts et al. Modulation of Protease Activated Receptor 1 Influences Human Metapneumovirus Disease Severity in a Mouse Model. PLoS One. 2013; 8(8): e72529.
- List of publications using SCH 530348 (Axon 1755) purchased from Axon Medchem
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