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ML 161
- Soluble in DMSO and EtOH
- MF: C17H17BrN2O2
- MW: 361.23
Description
ML 161 is an allosteric protease-activated receptor 1 (PAR1) inhibitor that blocks PAR1-mediated platelet activation with nanomolar potency.
PAR1 is a thrombin-activated GPCR that controls platelet activation, vascular signaling and inflammatory responses. ML 161 is useful for studying allosteric PAR1 pharmacology and thrombin receptor-dependent platelet function.
Key Features
- Allosteric PAR1 inhibitor
- Blocks PAR1-mediated platelet activation
- Nanomolar potency in platelet activation assays
- Useful probe for thrombin receptor signaling
Applications
- PAR1 receptor pharmacology
- Platelet activation and aggregation studies
- Thrombosis and hemostasis research
- Allosteric GPCR inhibitor profiling
More Information
| Parent CAS No. | 423735-93-7 |
|---|---|
| Chemical Name | 2-bromo-N-(3-butyramidophenyl)benzamide |
| SMILES | C(NC1=CC=CC(NC(=O)CCC)=C1)(=O)C1=CC=CC=C1Br |
| MFCD | N.A. |
| InChi | InChI=1S/C17H17BrN2O2/c1-2-6-16(21)19-12-7-5-8-13(11-12)20-17(22)14-9-3-4-10-15(14)18/h3-5,7-11H,2,6H2,1H3,(H,19,21)(H,20,22) |
| InChiKey | DFOVLSMXPWPCFH-UHFFFAOYSA-N |
| CID | 1048267 |
| Short Description | PAR1 antagonist |
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