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I-191
- PAR2 antagonist I-191
- Soluble in DMSO
- MF: C23H26FN5O2
- MW: 423.48
Description
I-191 is a potent antagonist of protease activated receptor 2 (PAR2) with a pIC50 value of 7.1 in HT-29 cells. I-191 potently attenuated multiple PAR2-mediated intracellular signaling pathways leading to Ca2+ release, ERK1/2 phosphorylation, RhoA activation and inhibition of forskolin-induced cAMP accumulation.
More Information
| Parent CAS No. | 1690172-25-8 |
|---|---|
| Chemical Name | 4-(8-tert-Butyl-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine-2-carbonyl)-3,3-dimethylpiperazin-2-one |
| SMILES | C1C=C(C2C=C(C(C)(C)C)C3=NC(C(N4C(C)(C)C(=O)NCC4)=O)=CN3N=2)C=CC=1F |
| MFCD | N.A. |
| InChi | InChI=1S/C23H26FN5O2/c1-22(2,3)16-12-17(14-6-8-15(24)9-7-14)27-29-13-18(26-19(16)29)20(30)28-11-10-25-21(31)23(28,4)5/h6-9,12-13H,10-11H2,1-5H3,(H,25,31) |
| InChiKey | DTASTQAQBOZSRR-UHFFFAOYSA-N |
| CID | 117977934 |
| Short Description | PAR2 antagonist |
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