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Q94 hydrochloride
Axon 2055
- Parent CAS: 537009-12-4
Purity:
99%
- Soluble in DMSO
- MF: C21H17ClN2.HCl
- MW: 369.29
Description
Q94 hydrochloride is a PAR1/Gαq-selective allosteric inhibitor and negative allosteric modulator. It selectively disrupts PAR1 coupling to Gαq-dependent signaling rather than broadly blocking all PAR1 functions.
PAR1 is a thrombin-activated GPCR that can signal through multiple G proteins and β-arrestin pathways. Q94 is useful for studying biased or pathway-selective PAR1 pharmacology, especially Gαq-dependent signaling mechanisms.
Key Features
- PAR1/Gαq-selective allosteric inhibitor
- Negative allosteric modulator of PAR1 signaling
- Selectively blocks PAR1-Gαq interaction
- Useful for pathway-biased GPCR pharmacology
Applications
- PAR1 signaling assays
- Gαq pathway studies
- Thrombin receptor pharmacology
- Biased GPCR signaling research
More Information
| Parent CAS No. | 537009-12-4 |
|---|---|
| Chemical Name | 2-benzyl-1-(4-chlorobenzyl)-1H-benzo[d]imidazole hydrochloride |
| SMILES | C1(CC2=CC=CC=C2)N(CC2=CC=C(Cl)C=C2)C2=CC=CC=C2N=1.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C21H17ClN2.ClH/c22-18-12-10-17(11-13-18)15-24-20-9-5-4-8-19(20)23-21(24)14-16-6-2-1-3-7-16;/h1-13H,14-15H2;1H |
| InChiKey | WXIWQTVPWYFEHP-UHFFFAOYSA-N |
| CID | 16258217 |
| Short Description | PAR1 antagonist |
References
- X Ding et al. Thrombin induces fibroblast CCL2/JE production and release via coupling of PAR1 to Gαq and cooperation between ERK1/2 and Rho kinase signaling pathways. Mol. Biol. Cell, 2008, 19(6), 2520-2533.
- S Asteriti et al. Modulation of PAR1 signalling by benzimidazole compounds. Br. J. Pharmacol. 2012, 167, 80–94.
- PF Mercer et al. Pulmonary Epithelium Is a Prominent Source of Proteinase-activated Receptor-1–inducible CCL2 in Pulmonary Fibrosis. Am. J. Resp. Critical Care Med. 2009, 179(5), 414-425.
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