Glucagon

Glucagon

Glucagon levels are elevated in diabetes and some liver diseases. Increased glucagon secretion leads to abnormal stimulation of glucagon receptors (GRs) and consequent elevated glucose production in the liver. Blocking glucagon receptor signaling has been proposed as a potential treatment option for diabetes and other conditions associated with hyperglycemia. The GR is a prototypical, Family B heptahelical G protein-coupled receptor (GPCR).

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More About Glucagon

Glucagon levels are elevated in diabetes and some liver diseases. Increased glucagon secretion leads to abnormal stimulation of glucagon receptors (GRs) and consequent elevated glucose production in the liver. Blocking glucagon receptor signaling has been proposed as a potential treatment option for diabetes and other conditions associated with hyperglycemia. The GR is a prototypical, Family B heptahelical G protein-coupled receptor (GPCR).[1]

[1] L. Krilov et al. Dual mode of glucagon receptor internalization: role of PKCα, GRKs and β-arrestins. Exp Cell Res. 2011 Dec 10;317(20):2981-94.

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