Neuropeptide somatostatin (SST) is a cyclic neuropeptide containing a disulfide bond and is produced by specialized cells in a large number of human organs and tissues. SST primarily acts as inhibitor of endocrine and exocrine secretion via the activation of five G-protein-coupled receptors (GPCR-A4 subfamily), named SST1-5. SST is ubiquitously expressed in humans, with high concentrations in brain, liver, lungs, pancreas, thyroid, gastrointestinal tract, and adrenal gland mainly acting as an inhibitor of exocrine and endocrine secretions on target organs. SST suppresses GH, prolactin, and TSH production from pituitary gland, insulin, glucagon and exocrine secretions from pancreas, and several gastrointestinal peptides. In the brain, SST acts as neuromodulator, with physiological effects on neuroendocrine, motor, and cognitive functions, and as neurotransmitter, exerting both stimulatory and inhibitory effects[1],[2]

[1] Classification and nomenclature of somatostatin receptors. Hoyer D. et al. Trends Pharmacol. Sci. 1995, 16, 86-88.
[2] F. Barbieri et al. Peptide receptor targeting in cancer: the somatostatin paradigm. Int. J. Pept. 2013, 926295.

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Axon ID Name Description From price
1607 FK 960 Somatostatin agonist €95.00
3198 FK962 Enhancer of somatostatin release €95.00
3840 Paltusotine Potent, selective, and orally bioavailable SST2 agonist €240.00
4064 Paltusotine dihydrochloride Potent, selective, and orally bioavailable SST2 agonist €160.00

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