GABA-B

A second member of the class C family of GPCRs comprises the GABA-B receptors (GABAB1-3): metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA) that are linked via G-proteins to potassium channels. They can stimulate the opening of K+ channels which brings the neuron closer to the equilibrium potential of K+, hyperpolarizing the neuron. This prevents sodium channels from opening, action potentials from firing, and VDCCs from opening, and so stops neurotransmitter release. Thus GABAB receptors are considered inhibitory receptors[1].


[1] The ‘ABC’of GABA receptors: a brief review. M. Chebib, G.A.R. Johnston. Clin. Exp. Pharmacol. Physiol. 1999, 26, 937-940

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1820 GS 39783 PAM of GABA-B Receptor €99.00

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