GPR84
GPR84 is activated by medium-chain FFAs (MCFAs) with 9-14 carbons. It is expressed mainly in the immune-related tissues, such as thymus, spleen, bone marrow, and peripheral blood leukocytes, and is significantly upregulated in monocytes/macrophages upon lipopolysaccharide (LPS) stimulation. In activated T cells, GPR84 has been found to regulate early interleukin 4 (IL-4) gene expression[1].
[1] J Wang et al. Medium-chain fatty acids as ligands for orphan G protein-coupled receptor GPR84. J Biol Chem. 2006 Nov 10;281(45):34457-64.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 4285 | Pyrone-211 | Potent GPR84 agonist; AKR1C3 inhibitor | Recently added | €210.00 |
| 2616 | ZQ-16 | Potent and selective GPR84 agonist that induces phosphorylation of ERK1/2 | €95.00 | |