mGluR7

mGluR7

Metabotropic glutamate receptor 7 (mGluR7) is a member of the group III family of mGluRs that bind to Gi and inhibit adenylate cyclase. It is the most highly conserved mGluR subtype in mammalian species, abundantly expressed in CNS regions implicated in fear and anxiety states such as amygdale and hippocampus. More studies has been shown that mGlu7 is a promising target for treatment of a range of disorders, including anxiety, post-traumatic stress disorder, depression, drug abuse, and schizophrenia.

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More About mGluR7

Metabotropic glutamate receptor 7 (mGluR7) is a member of the group III family of mGluRs that bind to Gi and inhibit adenylate cyclase. It is the most highly conserved mGluR subtype in mammalian species, abundantly expressed in CNS regions implicated in fear and anxiety states such as amygdale and hippocampus[1]. More studies has been shown that mGlu7 is a promising target for treatment of a range of disorders, including anxiety, post-traumatic stress disorder, depression, drug abuse, and schizophrenia[2].

[1] Z Callaerts-Vegh et al. Concomitant deficits in working memory and fear extinction are functionally dissociated from reduced anxiety in metabotropic glutamate receptor 7-deficient mice. J Neurosci. 2006 Jun 14;26(24):6573-82.
[2] B Campo et al. Characterization of an mGluR2/3 negative allosteric modulator in rodent models of depression. J Neurogenet. 2011 Dec;25(4):152-66.
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