GPR139

GPR139

GPR139 (a.k.a. or GPRg1 or GPCR12), is an orphan receptor first identified as a rhodopsin family GPCR with exclusive expression in the central nervous system. Its closest homolog, GPR142, however, is expressed primarily in the pancreas and other peripheral tissues. GPR139 is coupled with Gq signaling and appears to be constitutively active when recombinantly expressed in mammalian cells.

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  • JNJ 63533054
    2569
    JNJ 63533054
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  • NCRW0005-F05
    2609
    NCRW0005-F05
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More About GPR139

GPR139 (a.k.a. or GPRg1 or GPCR12), is an orphan receptor first identified as a rhodopsin family GPCR with exclusive expression in the central nervous system. Its closest homolog, GPR142, however, is expressed primarily in the pancreas and other peripheral tissues[1]. GPR139 is coupled with Gq signaling and appears to be constitutively active when recombinantly expressed in mammalian cells[2].

[1] C. Liu et al. GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine. Mol Pharmacol. 2015 Nov;88(5):911-25.
[2] CA Dvorak et al. Identification and SAR of Glycine Benzamides as Potent Agonists for the GPR139 Receptor.ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8.

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