GPR40

The GPR40 and GPR120 receptors are also known as the Free Fatty Acid Receptor (1 and 4 respectively). All of them are members of the A11 subfamily of GPCR receptors. Four (1-4) subtypes of the FFA receptors are known to date. They are a critical component of the body’s nutrient sensing apparatus, and small molecule agonists and antagonists of these receptors show considerable promise in the management of diabetes and its complications[1]. Unlike the classic ‘lock and key’ relationship between receptors and their ligands, nutrient receptors are considered to be promiscuous in that they can be activated by a range of ligands.

FFA receptor subtypes listed: GPR40, GPR120


[1] Free fatty acid receptors: emerging targets for treatment of diabetes and its complications V. Vangaveti, V. Shashidhar, G. Jarrod, B.T. Baune, R.L. Kennedy. Ther. Adv. Endocrinol. Metab. 2010, 1, 165-175

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Axon ID Name Description From price
2405 AMG 837 calcium salt Orally bioavailable partial agonist of GPR40 (FFA1) €110.00
2013 GW 9508 GPR40 receptor agonist (FFA1) €85.00

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