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DC260126
Axon 3057
CAS:
346692-04-4
Purity:
99%
- Soluble in DMSO
- MF: C16H18FNO2S
- MW: 307.38
Description
DC260126 is a GPR40 antagonist with an IC50 value of 6.58 μM. DC260126 improves insulin tolerance but not glucose tolerance in obese Zucker rats. Although DC260126 could not provide benefit for improving hyperglycemia, it could protect against pancreatic b-cells dysfunction through reducing overload of b-cells, and it increases insulin sensitivity possibly via alleviation of hyperinsulinemia in db/db mice.
More Information
| Parent CAS No. | 346692-04-4 |
|---|---|
| Chemical Name | N-(4-Butylphenyl)-4-fluorobenzenesulfonamide |
| SMILES | C1(F)C=CC(S(NC2C=CC(CCCC)=CC=2)(=O)=O)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C16H18FNO2S/c1-2-3-4-13-5-9-15(10-6-13)18-21(19,20)16-11-7-14(17)8-12-16/h5-12,18H,2-4H2,1H3 |
| InChiKey | CNGHPXKWPGIDSK-UHFFFAOYSA-N |
| CID | 2843133 |
| Short Description | GPR40 antagonist |
References
- H Hu et al. A novel class of antagonists for the FFAs receptor GPR40. Biochem Biophys Res Commun. 2009 Dec 18;390(3):557-63.
- X Zhang et al. DC260126, a small-molecule antagonist of GPR40, improves insulin tolerance but not glucose tolerance in obese Zucker rats. Biomed Pharmacother. 2010 Nov;64(9):647-51.
- P Sun et al. DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. PLoS One. 2013 Jun 11;8(6):e66744.
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