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TUG-1375
Axon 3078
CAS:
2247372-59-2
- Optical Purity: 98% e.e.
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C22H19ClN2O4S
- MW: 442.92
Description
TUG-1375 is a potent free fatty acid receptor 2 (FFA2/GPR43) agonist with a pKi value of 6.69. TUG-1375 has high solubility, high chemical, microsomal, and hepatocyte stability, and favorable pharmacokinetic properties and was confirmed to induce human neutrophil mobilization and to inhibit lipolysis in murine adipocytes.
More Information
| Parent CAS No. | 2247372-59-2 |
|---|---|
| Chemical Name | (2R,4R)-2-(2-Chlorophenyl)-3-(4-(3,5-dimethylisoxazol-4-yl)benzoyl)thiazolidine-4-carboxylic acid |
| SMILES | C1C=C(C(=O)N2[C@H](C(O)=O)CS[C@@H]2C2C(Cl)=CC=CC=2)C=CC=1C1=C(C)ON=C1C |&1:6,12,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C22H19ClN2O4S/c1-12-19(13(2)29-24-12)14-7-9-15(10-8-14)20(26)25-18(22(27)28)11-30-21(25)16-5-3-4-6-17(16)23/h3-10,18,21H,11H2,1-2H3,(H,27,28)/t18-,21+/m0/s1 |
| InChiKey | RZAMDGBOOPJHJQ-GHTZIAJQSA-N |
| CID | 138319694 |
| Short Description | GPR43 agonist |
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