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GSK 137647A

 - GSK137647
Axon 2582
CAS:  349085-82-1
Purity:  99%
  • Soluble in DMSO and EtOH
  • MF:  C16H19NO3S
  • MW:  305.39

Description

GSK 137647A (GSK137647) is a potent and selective FFA4/GPR120 agonist (pEC50 value 6.3 nM for hFFA4) with >100-fold selectivity over a panel of 65 targets including FFA1-FFA3. GSK137647A reproduces the secretion of active GLP-1 mediated by long-chain Fas (LCFAs), especially ALA.

FFA4 (GPR120) signaling plays a critical role in mitigating inflammation and regulating metabolic disorders like type 2 diabetes. GSK137647A serves as a vital tool for probing these biological pathways in biochemical, cellular, and in vivo disease models.

Key Features

  • Free fatty acid receptor 4 (FFA4/GPR120) agonist
  • PEC50 6.3 nM for hFFA4
  • >100-fold selectivity over a panel of 65 targets including FFA1-FFA3
  • Modulates FFA4/GPR120-dependent signaling

Applications

  • FFA4/GPR120 pharmacology and target-validation studies
  • FFA4/GPR120 pathway and cell signaling assays
  • Disease-model research related to inflammation, diabetes
  • Metabolic pathway and biomarker-response studies

More Information

Parent CAS No. 349085-82-1
Chemical Name N-mesityl-4-methoxybenzenesulfonamide
SMILES C1(S(NC2=C(C)C=C(C)C=C2C)(=O)=O)=CC=C(OC)C=C1
MFCD MFCD02007969
InChi InChI=1S/C16H19NO3S/c1-11-9-12(2)16(13(3)10-11)17-21(18,19)15-7-5-14(20-4)6-8-15/h5-10,17H,1-4H3
InChiKey FQUAFMNPXPXOJE-UHFFFAOYSA-N
CID 743974
Short Description FFA4/GPR120 agonist

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