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AR 420626

Axon 2794
CAS:  1798310-55-0
Purity:  99%
  • Soluble in DMSO
  • MF:  C21H18Cl2N2O3
  • MW:  417.29

Description

AR420626 is an allosteric agonist of the short-chain fatty-acid receptor FFA3 (GPR41), with a reported pEC50 value of 5.74. It activates FFA3 independently of the endogenous orthosteric short-chain fatty-acid binding site.

AR420626 has been used to investigate intestinal FFA3 signaling and mucosal defense. In rat studies it enhanced protective responses and reduced NSAID-induced small-intestinal injury through a pathway involving glucagon-like peptide-2 (GLP-2).

Key Features

  • Allosteric FFA3/GPR41 agonist
  • pEC50: 5.74
  • Activates a short-chain fatty-acid receptor pathway
  • Enhances GLP-2-associated mucosal protection

Applications

  • FFA3 / GPR41 receptor research
  • Short-chain fatty-acid signaling
  • Intestinal mucosal-defense studies
  • GLP-2 pathway research
  • NSAID enteropathy models

More Information

Parent CAS No. 1798310-55-0
Chemical Name N-(2,5-Dichlorophenyl)-4-(furan-2-yl)-2-methyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxamide
SMILES C1CC2NC(C)=C(C(=O)NC3C=C(Cl)C=CC=3Cl)C(C3=CC=CO3)C=2C(=O)C1
MFCD N.A.
InChi InChI=1S/C21H18Cl2N2O3/c1-11-18(21(27)25-15-10-12(22)7-8-13(15)23)20(17-6-3-9-28-17)19-14(24-11)4-2-5-16(19)26/h3,6-10,20,24H,2,4-5H2,1H3,(H,25,27)
InChiKey GGTYQECCGLBHGS-UHFFFAOYSA-N
CID 91885415
Short Description GPR41 agonist

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