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GW 9508
Axon 2013
CAS:
885101-89-3
Purity:
100%
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C22H21NO3
- MW: 347.41
Description
Potent and selective agonist for the free fatty acid receptor FFA1 (GPR40)
More Information
| Parent CAS No. | 885101-89-3 |
|---|---|
| Chemical Name | 3-(4-(3-phenoxybenzylamino)phenyl)propanoic acid |
| SMILES | C1(CCC(O)=O)=CC=C(NCC2=CC=CC(OC3=CC=CC=C3)=C2)C=C1 |
| MFCD | MFCD09753282 |
| InChi | InChI=1S/C22H21NO3/c24-22(25)14-11-17-9-12-19(13-10-17)23-16-18-5-4-8-21(15-18)26-20-6-2-1-3-7-20/h1-10,12-13,15,23H,11,14,16H2,(H,24,25) |
| InChiKey | DGENZVKCTGIDRZ-UHFFFAOYSA-N |
| CID | 11595431 |
| Short Description | GPR40 agonist |
References
- CP Briscoe et al. Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br. J. Pharmacol. 2006, 148(5), 619-628.
- T Fujita et al. A GPR40 agonist GW9508 suppresses CCL5, CCL17, and CXCL10 induction in keratinocytes and attenuates cutaneous immune inflammation. J. Invest. Dermatol. 2011, 131(8), 1660-1667.
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