GPR120
The GPR40 and GPR120 receptors are also known as the Free Fatty Acid Receptor (1 and 4 respectively). All of them are members of the A11 subfamily of GPCR receptors. Four (1-4) subtypes of the FFA receptors are known to date. They are a critical component of the body’s nutrient sensing apparatus, and small molecule agonists and antagonists of these receptors show considerable promise in the management of diabetes and its complications[1]. Unlike the classic ‘lock and key’ relationship between receptors and their ligands, nutrient receptors are considered to be promiscuous in that they can be activated by a range of ligands.
FFA receptor subtypes listed: GPR40, GPR120
[1] Free fatty acid receptors: emerging targets for treatment of diabetes and its complications V. Vangaveti, V. Shashidhar, G. Jarrod, B.T. Baune, R.L. Kennedy. Ther. Adv. Endocrinol. Metab. 2010, 1, 165-175
Axon ID | Name | Description | From price | |
---|---|---|---|---|
2582 | GSK 137647A | Potent and selective FFA4/GPR120 agonist | €70.00 | |
2075 | TUG 891 | Potent and selective GPR120 (FFA4) agonist | €110.00 |