TLR8

Originally associated with the recognition of single-stranded RNA of viral origin, there is now evidence that human TLR8 is also able to sense bacterial RNA released within phagosomal vacuoles, inducing the production of both nuclear factor (NF)-κB-dependent cytokines and type I interferons (IFNs), such as IFN-β. The functions of TLR8 extend beyond the recognition of foreign pathogens and include cross-talk with other endosomal TLRs, a process that may also have a role in the generation of autoimmunity.[1]


[1] J.L. Cervantes et al. TLR8: the forgotten relative revindicated. Cell Mol Immunol. 2012 Nov;9(6):434-8.

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2783 Motolimod Highly potent and selective TLR8 agonist  Recently added €145.00

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