FGFR

The fibroblast growth factor receptors (FGFRs, RTK class V, FGF receptor family) include the four highly conserved transmembrane receptor tyrosine kinases FGFR1, FGFR2, FGFR3, and FGFR4. One additional receptor, FGFR5 (FGFRL-1), is devoid of kinase activity but able to bind FGFs and may act as a negative regulator of signaling[1]. The FGF signaling pathway plays a critical role in many physiological processes during embryonal development and maintenance of adult organ systems, including angiogenesis and wound repair, cell proliferation, migration, differentiation, and cell survival. Aberrations in this signaling pathway can give rise to  tumor progression and growth of multiple cancer types. In addition, it may serve as a mechanism of resistance to antivascular endothelial growth factor targeted therapy. As such this pathway has emerged as a relevant therapeutic target, and several agents that can inhibit or modulate its signaling are in various stages of development[2].


[1] Structural and functional diversity in the FGF receptor multigene family. D.E. Johnson, L.T. Williams. Adv Cancer Res. 1993, 60, 1-41.
[2] FGF receptor inhibitors: role in cancer therapy. Daniele G, Corral J, Molife LR, de Bono JS. Curr. Oncol. Rep. 2012  14(2):111-119.

 

15 Item(s)

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Axon ID Name Description From price
1419 AB 1010 PDGFR, c-KIT and FGFR3 tyrosine kinase inhibitor €70.00
1917 AZD 4547 Potent and selective FGFR inhibitor €85.00
1942 E 3810 dihydrochloride Dual VEGFR/FGFR tyrosine kinase inhibitor €95.00
1981 LY 2874455 Potent and selective FGFR inhibitor €110.00
2648 Nintedanib RTK inhibitor with antiangiogenic and antineoplastic activities €75.00
1775 NVP-BGJ398 Inhibitor of FGFR tyrosine kinases 1, 2 ,3 and 4 €90.00
1944 NVP-BGJ398 phosphate Inhibitor of FGFR tyrosine kinases 1, 2 ,3 and 4 €105.00
2098 PD 161570 Selective FGFR1 inhibitor €75.00
1673 PD 173074 FGFR1 and FGFR3 inhibitor €80.00
2234 SSR 128129E Allosteric inhibitor of FGF receptor signaling €99.00
2129 Stem Cell 3i inhibitor Set Set of FGFR inhibitor SU5402 (Axon 1667), MEK inhibitor PD184352 (Axon 1368) and GSK-3 inhibitor CHIR99021 (Axon 1386) €155.00
5007 Stem Cell 5i inhibitor Set Set of five inhibitors for neural differentiation of human pluripotent stem cells. €240.00
5006 Stem Cell CSD inhibitor Set Set of CHIR 99021, SU5402, and DAPT, inhibitors of GSK-3, FGFR, and γ-secretase, resp. €155.00
1667 SU 5402 Fibroblast growth factor receptor (FGFR) inhibitor €65.00
1891 SU 6668 Inhibitor of RTK targeting PDGFR, VEGF and FGFR €105.00

15 Item(s)

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