FGFR
The fibroblast growth factor receptors (FGFRs, RTK class V, FGF receptor family) include the four highly conserved transmembrane receptor tyrosine kinases FGFR1, FGFR2, FGFR3, and FGFR4. One additional receptor, FGFR5 (FGFRL-1), is devoid of kinase activity but able to bind FGFs and may act as a negative regulator of signaling[1]. The FGF signaling pathway plays a critical role in many physiological processes during embryonal development and maintenance of adult organ systems, including angiogenesis and wound repair, cell proliferation, migration, differentiation, and cell survival. Aberrations in this signaling pathway can give rise to tumor progression and growth of multiple cancer types. In addition, it may serve as a mechanism of resistance to antivascular endothelial growth factor targeted therapy. As such this pathway has emerged as a relevant therapeutic target, and several agents that can inhibit or modulate its signaling are in various stages of development[2].
[1] Structural and functional diversity in the FGF receptor multigene family. D.E. Johnson, L.T. Williams. Adv Cancer Res. 1993, 60, 1-41.
[2] FGF receptor inhibitors: role in cancer therapy. Daniele G, Corral J, Molife LR, de Bono JS. Curr. Oncol. Rep. 2012 14(2):111-119.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 1419 | AB 1010 | PDGFR, c-KIT and FGFR3 tyrosine kinase inhibitor | €70.00 | |
| 2930 | Alofanib | Allosteric inhibitor of FGFR2 | €90.00 | |
| 1917 | AZD4547 | Potent and selective FGFR inhibitor | €85.00 | |
| 1942 | E 3810 dihydrochloride | Dual VEGFR/FGFR tyrosine kinase inhibitor | €90.00 | |
| 4067 | Formononetin | Potent FGFR2 inhibitor | €120.00 | |
| 3165 | Lenvatinib | Multi-targeted receptor tyrosine kinase inhibitor | €70.00 | |
| 1981 | LY 2874455 | Potent and selective FGFR inhibitor | €110.00 | |
| 2648 | Nintedanib | RTK inhibitor with antiangiogenic and antineoplastic activities | €70.00 | |
| 1775 | NVP-BGJ398 | Inhibitor of FGFR tyrosine kinases 1, 2 ,3 and 4 | €80.00 | |
| 1944 | NVP-BGJ398 phosphate | Inhibitor of FGFR tyrosine kinases 1, 2 ,3 and 4 | €90.00 | |
| 2098 | PD161570 | Selective FGFR1 inhibitor | €75.00 | |
| 1673 | PD173074 | FGFR1 and FGFR3 inhibitor | €75.00 | |
| 2953 | Roblitinib | First-in-class, highly selective and potent FGFR4 inhibitor | €125.00 | |
| 2234 | SSR 128129E | Allosteric inhibitor of FGF receptor signaling | €110.00 | |
| 2129 | Stem Cell 3i inhibitor Set | Set of FGFR inhibitor SU5402 (Axon 1667), MEK inhibitor PD184352 (Axon 1368) and GSK-3 inhibitor CHIR99021 (Axon 1386) | €130.00 | |
| 5007 | Stem Cell 5i inhibitor Set | Set of five inhibitors for neural differentiation of human pluripotent stem cells. | €200.00 | |
| 5006 | Stem Cell CSD inhibitor Set | Set of CHIR99021, SU5402, and DAPT, inhibitors of GSK-3, FGFR, and γ-secretase, resp. | €140.00 | |
| 1667 | SU 5402 | Fibroblast growth factor receptor (FGFR) inhibitor | €60.00 | |
| 1891 | SU 6668 | Inhibitor of RTK targeting PDGFR, VEGF and FGFR | €100.00 | |
| 3624 | Toceranib phosphate | Multi-targeted receptor tyrosine kinase inhibitor | €60.00 | |
| 3973 | XL-228 | Multitargeted protein kinase inhibitor (IGF1R, Aurora,FGFR, ABL,ALK and SRC) | Inquire | |