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PD161570
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C26H35Cl2N7O
- MW: 532.51
Description
PD161570 is a selective FGFR inhibitor with reported IC50 values of 40 nM for FGFR1, 262 nM for PDGFR and 3700 nM for EGFR. It suppresses constitutive FGFR1 phosphorylation in reported cellular models.
FGFR signaling supports proliferation, survival and oncogenic growth in multiple tumor types. PD161570 is useful for studying FGFR1-dependent signaling, receptor tyrosine kinase selectivity and FGFR-driven cancer-cell proliferation.
Key Features
- Selective FGFR inhibitor
- Reported IC50: 40 nM for FGFR1
- Selectivity over PDGFR and EGFR in reported assays
- Blocks FGFR1 phosphorylation and growth in reported tumor cells
Applications
- FGFR1 kinase assays
- FGF signaling studies
- Ovarian cancer model research
- RTK inhibitor selectivity profiling
More Information
| Parent CAS No. | 192705-80-9 |
|---|---|
| Chemical Name | 1-tert-butyl-3-(6-(2,6-dichlorophenyl)-2-(4-(diethylamino)butylamino)pyrido[2,3-d]pyrimidin-7-yl)urea |
| extra_info | . |
| SMILES | N(C1=NC2C(C=C1C1=C(Cl)C=CC=C1Cl)=CN=C(NCCCCN(CC)CC)N=2)C(NC(C)(C)C)=O |
| MFCD | MFCD16618403 |
| InChi | InChI=1S/C26H35Cl2N7O/c1-6-35(7-2)14-9-8-13-29-24-30-16-17-15-18(21-19(27)11-10-12-20(21)28)23(31-22(17)32-24)33-25(36)34-26(3,4)5/h10-12,15-16H,6-9,13-14H2,1-5H3,(H3,29,30,31,32,33,34,36) |
| InChiKey | MKVMEJKNLUWFSQ-UHFFFAOYSA-N |
| CID | 5328135 |
| Short Description | FGFR inhibitor |
References
- MC Schroeder et al. Soluble 2-Substituted Aminopyrido[2,3-d]pyrimidin-7-yl Ureas. Structure-Activity Relationships against Selected Tyrosine Kinases and Exploration of in Vitro and in Vivo Anticancer Activity. J. Med. Chem. 2001, 44(12), 1915-1926.
- BL Batley et al. Inhibition of FGF-1 receptor tyrosine kinase activity by PD 161570, a new protein-tyrosine kinase inhibitor. Life Sciences 1997, 62(2), 143-150.
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