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LY 2874455
- LM 1476
- Soluble in DMSO
- MF: C21H19Cl2N5O2
- MW: 444.31
Description
LY 2874455 is a potent pan-FGFR inhibitor with reported IC50 values of 2.8 nM, 2.6 nM, 6.4 nM and 6 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. It blocks FGFR autophosphorylation and downstream FGF signaling.
FGFR signaling controls proliferation, survival, angiogenesis and developmental pathways and is frequently dysregulated in cancer. LY 2874455 is useful for studying pan-FGFR blockade in tumor, vascular and receptor tyrosine kinase models.
Key Features
- Potent pan-FGFR inhibitor
- Reported IC50: 2.6-6.4 nM across FGFR1-4
- Blocks FGFR autophosphorylation and downstream signaling
- Relevant to FGFR-driven cancer and angiogenesis research
Applications
- FGFR kinase assays
- FGF signaling pathway studies
- Oncology and angiogenesis models
- RTK inhibitor selectivity profiling
More Information
| Parent CAS No. | 1254473-64-7 |
|---|---|
| Chemical Name | (R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol |
| MFCD | MFCD22124884 |
| Short Description | FGFR inhibitor |
References
- G ZHao et al. A Novel, Selective Inhibitor of Fibroblast Growth Factor Receptors That Shows A Potent Broad-spectrum of Anti-tumor Activity in Several Tumor Xenograft Models. Mol. Cancer Ther. 2011, 10, 2200.
- AN Brooks et al. Molecular Pathways: Fibroblast Growth Factor Signaling: A New Therapeutic Opportunity in Cancer. Clin. Cancer Res. 2012, 18, 1855.
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