Calcium Sensing

Calcium Sensing

The calcium-sensing receptor (CaSR), a receptor which senses extracellular levels of calcium ion, is also classified as a member of the family of class C GPCRs. The release of parathyroid hormone (PTH) is inhibited in response to elevations in plasma calcium concentrations and activation of the calcium receptor by activating the phospholipase C (PLC) pathway, presumably through a Gqα type of G protein.

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  • CaSR antagonist 18c
    1732
    CaSR antagonist 18c
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  • Calhex 231 hydrochloride
    1818
    Calhex 231 hydrochloride
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    From $108.90

  • DJ-V-159
    2942
    DJ-V-159
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    From $104.50

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More About Calcium Sensing

The calcium-sensing receptor (CaSR), a receptor which senses extracellular levels of calcium ion, is also classified as a member of the family of class C GPCRs. The release of  parathyroid hormone (PTH) is inhibited in response to elevations in plasma calcium concentrations and activation of the calcium receptor by activating the phospholipase C (PLC) pathway, presumably through a Gqα type of G protein[1].

[1] Calcium-sensing receptor and calcimimetic agents. J.W. Coburn, L. Elangovan, W.G. Goodman, J.M. Frazaõ. Kidney Int. Suppl. 1999, 73, S52-58.

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