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CaSR antagonist 18c

Axon 1732
CAS:  802916-30-9
  • Optical Purity:  Optically pure
  • Soluble in DMSO
  • MF:  C32H35N3O6
  • MW:  557.64

Description

CaSR antagonist 18c is a calcium-sensing receptor (CaSR) antagonist with an IC50 value of 76 nM.

CaSR regulates calcium homeostasis, parathyroid hormone secretion and bone metabolism. CaSR antagonist 18c is useful for studying calcilytic pharmacology and CaSR-dependent endocrine signaling relevant to anabolic bone research.

Key Features

  • CaSR antagonist with nanomolar potency
  • IC50: 76 nM
  • Modulates calcium-sensing receptor signaling
  • Relevant to parathyroid hormone and bone metabolism research

Applications

  • CaSR receptor pharmacology
  • Calcium homeostasis studies
  • Bone metabolism and osteoporosis models
  • GPCR antagonist assay development

More Information

Parent CAS No. 802916-30-9
Chemical Name (S)-6-(1-hydroxy-3-phenylpropan-2-ylamino)-N-(2-phenoxyethyl)-2-(3,4,5-trimethoxyphenyl)nicotinamide
SMILES N1C(N[C@H](CO)CC2C=CC=CC=2)=CC=C(C(NCCOC2C=CC=CC=2)=O)C=1C1C=C(OC)C(OC)=C(OC)C=1 |&1:3,r|
MFCD N.A.
InChi InChI=1S/C32H35N3O6/c1-38-27-19-23(20-28(39-2)31(27)40-3)30-26(32(37)33-16-17-41-25-12-8-5-9-13-25)14-15-29(35-30)34-24(21-36)18-22-10-6-4-7-11-22/h4-15,19-20,24,36H,16-18,21H2,1-3H3,(H,33,37)(H,34,35)/t24-/m0/s1
InChiKey FCBOUJYKAGWYQM-DEOSSOPVSA-N
CID 11410354
Short Description CaSR antagonist

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