CRF1

The Secretin family is a small family of 15 GPCRs (GPCR-B1) that all have an extracellular hormone-binding domain and bind peptide hormones. The members of this family are the calcitonin and calcitonin-like receptors (CALCR, CALCRL); the corticotropin-releasing hormone receptors (CRHR1, CRHR2); the glucagon receptor (GCGR); the gastric inhibitory polypeptide receptor (GIPR); the glucagon-like peptide receptors (GLP1R, GLP2R); the growth-hormone-releasing hormone receptor (GHRHR); the adenylate cyclase activating polypeptide receptor (PAC1/ADCYAP1R1); the parathyroid hormone receptors (PTHR1, PTHR2); the secretin receptor (SCTR); and the vasoactive intestinal peptide receptors (VIPR1, VIPR2).
The corticotropin releasing hormone receptor (CRF1, or CRHR1) is likely to be involved in mental disorders, and both infection and autoimmune disorders[1].


[1] CRHR1 Receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists. K.C. Rice et al. Bioorg. Med. Chem. 2002, 10, 175–183.

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Axon ID Name Description From price
1321 Antalarmin hydrochloride CRF1 antagonist €105.00
1116 CP 154526 hydrochloride CRF1 antagonist €115.00
1799 SSR 125543A Potent, selective, and orally active corticotropin-releasing factor 1 receptor (CRF1) antagonist €160.00

3 Item(s)

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