THR

THR

Thyroid hormone (TH aka triiodothyronine or T3) exerts a pleiotropic effect on development, differentiation, and metabolism through thyroid hormone receptors (TR or THR). In part because of associated hypercholesterolemia, hypothyroidism is associated with increased rates of atherosclerosis, while excessive levels of TH can lead to adverse effects, particularly in heart and bone. The beneficial metabolic effects of TH are mediated by the thyroid hormone receptor β isoform (THR-β, the predominant liver TH receptor), while the adverse heart and bone effects are primarily due to the interaction of TH with the THR-α.

Read More
sort-descending
  • MGL-3196
    2657
    MGL-3196
    The price depends on the options chosen on the product page

    From $99.00

  • Sobetirome
    4126
    Sobetirome
    The price depends on the options chosen on the product page

    From $99.00

2 Items

More About THR

Thyroid hormone (TH aka triiodothyronine or T3) exerts a pleiotropic effect on development, differentiation, and metabolism through thyroid hormone receptors (TR or THR)[1]. In part because of associated hypercholesterolemia, hypothyroidism is associated with increased rates of atherosclerosis, while excessive levels of TH can lead to adverse effects, particularly in heart and bone. The beneficial metabolic effects of TH are mediated by the thyroid hormone receptor β isoform (THR-β, the predominant liver TH receptor), while the adverse heart and bone effects are primarily due to the interaction of TH with the THR-α[2].

[1] K Moriyama et al. Molecular characterization of human thyroid hormone receptor β isoform 4. Endocr Res. 2016;41(1):34-42.
[2] MJ Kelly et al. Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196). J Med Chem. 2014 May 22;57(10):3912-23.

Loading...