5-HT6

The 5-HT6R is among the latest identified members of the 5-HT receptor family and is a particularly interesting receptor subtype because of its relatively low level of sequence homology (<50%) compared to other serotonin receptors. They include a short third cytoplasmatic loop and a long C-terminal tail, and one intron located in the middle of the third cytoplasmatic loop, as compared to most other serotonergic receptors. The 5-HT6R has shown enormous expectation as a drug target for the development of cognitive enhancers, based on localization, pharmacology, and behavioral data accumulated[1]. Since cognition dysfunction is one of the primary manifestations of several neurodegenerative diseases such as Alzheimer’s disease (AD), the localization of 5-HT6 receptors in brain areas involved in learning and memory processes has identified this receptor as a putative target for AD[2].

5-HT receptor subtypes listed: 5-HT1A5-HT1B5-HT1D5-HT1F5-HT2 ,5-HT2A5-HT2C5-HT45-HT5A5-HT65-HT7


[1] D. Marazziti et al. Serotonin receptors of type 6 (5-HT6): from neuroscience to clinical pharmacology. Curr. Med. Chem. 2013, 20, 371-377.
[2] B. Benhamú et al. Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease. J. Med. Chem. 2014, 57, 7160-7181.

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Axon ID Name Description From price
1575 5-HT6 antagonist 29 Selective brain penetrant 5-HT6 receptor antagonist €90.00
1146 Clozapine Atypical antipsychotic €45.00
2144 Lu AE58054 hydrochloride Selective 5-HT6 antagonist with good oral bioavailability Inquire
1849 MS 245 oxalate 5-HT6 antagonist €105.00
1298 Olanzapine Atypical antipsychotic €75.00
1330 RO 04-6790 hydrochloride 5-HT6 antagonist €95.00
1099 SB 271046 hydrochloride 5-HT6 antagonist €95.00
1382 SB 742457 hydrochloride 5-HT6 antagonist €80.00
1927 SGS 518 Selective 5-HT6 antagonist €95.00
1710 WAY 208466 dihydrochloride Potent and selective 5-HT6 receptor agonist €120.00

10 Item(s)

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