The 5-HT6R is among the latest identified members of the 5-HT receptor family and is a particularly interesting receptor subtype because of its relatively low level of sequence homology (<50%) compared to other serotonin receptors. They include a short third cytoplasmatic loop and a long C-terminal tail, and one intron located in the middle of the third cytoplasmatic loop, as compared to most other serotonergic receptors. The 5-HT6R has shown enormous expectation as a drug target for the development of cognitive enhancers, based on localization, pharmacology, and behavioral data accumulated[1]. Since cognition dysfunction is one of the primary manifestations of several neurodegenerative diseases such as Alzheimer’s disease (AD), the localization of 5-HT6 receptors in brain areas involved in learning and memory processes has identified this receptor as a putative target for AD[2].