The 5-HT6R is among the latest identified members of the 5-HT receptor family and is a particularly interesting receptor subtype because of its relatively low level of sequence homology (<50%) compared to other serotonin receptors. They include a short third cytoplasmatic loop and a long C-terminal tail, and one intron located in the middle of the third cytoplasmatic loop, as compared to most other serotonergic receptors. The 5-HT6R has shown enormous expectation as a drug target for the development of cognitive enhancers, based on localization, pharmacology, and behavioral data accumulated. Since cognition dysfunction is one of the primary manifestations of several neurodegenerative diseases such as Alzheimer’s disease (AD), the localization of 5-HT6 receptors in brain areas involved in learning and memory processes has identified this receptor as a putative target for AD.
5-HT receptor subtypes listed: 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1F, 5-HT2 ,5-HT2A, 5-HT2C, 5-HT4, 5-HT5A, 5-HT6, 5-HT7
 D. Marazziti et al. Serotonin receptors of type 6 (5-HT6): from neuroscience to clinical pharmacology. Curr. Med. Chem. 2013, 20, 371-377.
 B. Benhamú et al. Serotonin 5-HT6 receptor antagonists for the treatment of cognitive deficiency in Alzheimer's disease. J. Med. Chem. 2014, 57, 7160-7181.
|Axon ID||Name||Description||From price|
|1575||5-HT6 antagonist 29||Selective brain penetrant 5-HT6 receptor antagonist||€90.00|
|2144||Lu AE58054 hydrochloride||Selective 5-HT6 antagonist with good oral bioavailability||Inquire|
|1849||MS 245 oxalate||5-HT6 antagonist||€105.00|
|1330||RO 04-6790 hydrochloride||5-HT6 antagonist||€95.00|
|1099||SB 271046 hydrochloride||5-HT6 antagonist||€95.00|
|1382||SB 742457 hydrochloride||5-HT6 antagonist||€80.00|
|1927||SGS 518||Selective 5-HT6 antagonist||€95.00|
|1710||WAY 208466 dihydrochloride||Potent and selective 5-HT6 receptor agonist||€120.00|