Smoothened (SMO) is a G-protein coupled receptor protein (GPCR-F subfamily) encoded by the SMO gene of the Hedgehog (Hh) pathway. Most often SMO functions during embryonic development, in processes such as digit patterning in the chick limb bud and left–right asymmetry of vertebrate embryos. In addition, Smo function is also fundamental for the maintenance of tissue homeostasis in adults, and deregulated Smo signaling is implicated in tumorogenesis. Hh ligands signal through binding to the membrane receptor Patched (Ptc) to reverse the Ptc-mediated inhibition of signaling by the trans-membrane protein Smoothened (Smo). This allows Smo to activate the intracellular signaling components, resulting in stabilization of down-stream transcriptional activator(s) and activation of target genes.
 The cell biology of Smo signaling and its relationships with GPCRs. A. Ruiz-Gómez, et al. Biochim. Biophys. Acta 2007, 1768, 901–912.
 Regulation of Hedgehog signaling: a complex story. S.K. Ogden et al. Biochem. Pharm. 2004, 67(5), 805–814.
|Axon ID||Name||Description||From price|
|2356||BMS 833923||Oral antagonist of the Hedgehog signaling component Smoothened (SMO)||€75.00|
|1500||GDC 0449||Hedgehog (Hh) pathway inhibitor||€80.00|
|2196||LY 2940680||Small-molecule antagonist of the Smoothened (SMO) receptor||€120.00|
|1938||MRT 10||Smoothened (SMO) receptor antagonist||€125.00|
|1619||NVP-LDE225||Smoothened (SMO) antagonist||€85.00|
|2027||PF 5274857 hydrochloride||Smoothened (SMO) antagonist||€110.00|
|1690||Purmorphamine||Hedgehog signaling pathway activator||€105.00|