Smoothened (SMO)

Smoothened (SMO) is a G-protein coupled receptor protein (GPCR-F subfamily) encoded by the SMO gene of the Hedgehog (Hh) pathway. Most often SMO functions during embryonic development, in processes such as digit patterning in the chick limb bud and left–right asymmetry of vertebrate embryos. In addition, Smo function is also fundamental for the maintenance of tissue homeostasis in adults, and deregulated Smo signaling is implicated in tumorogenesis[1].  Hh ligands signal through binding to the membrane receptor Patched (Ptc) to reverse the Ptc-mediated inhibition of signaling by the trans-membrane protein Smoothened (Smo). This allows Smo to activate the intracellular signaling components, resulting in stabilization of down-stream transcriptional activator(s) and activation of target genes[2].

[1] The cell biology of Smo signaling and its relationships with GPCRs. A. Ruiz-Gómez, et al. Biochim. Biophys. Acta 2007, 1768, 901–912.
[2] Regulation of Hedgehog signaling: a complex story. S.K. Ogden et al. Biochem. Pharm. 2004, 67(5), 805–814.

7 Item(s)

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Axon ID Name Description From price
2356 BMS 833923 Oral antagonist of the Hedgehog signaling component Smoothened (SMO) €75.00
1500 GDC 0449 Hedgehog (Hh) pathway inhibitor €80.00
2196 LY 2940680 Small-molecule antagonist of the Smoothened (SMO) receptor €120.00
1938 MRT 10 Smoothened (SMO) receptor antagonist €125.00
1619 NVP-LDE225 Smoothened (SMO) antagonist €85.00
2027 PF 5274857 hydrochloride Smoothened (SMO) antagonist €110.00
1690 Purmorphamine Hedgehog signaling pathway activator €105.00

7 Item(s)

per page
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