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SAG dihydrochloride
Axon 4392
- Parent CAS: 912545-86-9
Purity:
99%
- Soluble in water, DMSO and EtOH
- MF: C28H28ClN3OS·2HCl
- MW: 562.98
Description
SAG dihydrochloride is a Smo agonist with an apparent Kd value of 59 nM (SAG/Smo complex) and an EC50 value of 3 nM (pathway activation in a mouse cultured cell assay, Shh-LIGHT2). SAG binds to the Smo heptahelical bundle in a manner that antagonizes cyclopamine action.
More Information
| Parent CAS No. | 912545-86-9 |
|---|---|
| Chemical Name | N-(trans-4-(Methylamino)cyclohexyl)-N-((3-(4-pyridyl)phenyl)methyl)-3-chloro-1-benzothiophene-2-carboxamide dihydrochloride |
| Short Description | SMO agonist |
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