GPR52
G-protein-coupled receptor 52 (GPR52) is an orphan Gs-coupled G-protein-coupled receptor. GPR52 inhibits dopamine D2 receptor signaling and activates dopamine D1/N-methyl-d-aspartate receptors via intracellular cAMP accumulation, and therefore, GPR52 agonists may have potential as a novel class of antipsychotics.[1]
[1] M. Setoh et al. Discovery of the first potent and orally available agonist of the orphan G-protein-coupled receptor 52. J Med Chem. 2014 Jun 26;57(12):5226-37.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2962 | FTBMT | Potent, selective and orally available GPR52 agonist | €125.00 | |
| 3522 | GPR52 Comp-43 | Highly potent and specific GPR52 antagonist | €90.00 | |