PGI2 (IP)

The Prostacyclin (PGI2) receptor , also termed the prostaglandin I2 receptor or just IP, is coupled to a guanosine nucleotide-binding α-stimulatory protein (Gαs). IP is found on a variety of cell types and exhibits broad physiological effects. PGI2 regulates both the innate and adaptive immune systems and its effects are, for the most part, thought to be anti-inflammatory or immunosuppressive in nature. For a long time, PGI2 has been understood to play a role in cardiovascular health, specifically having powerful vasodilatory effects via relaxation of smooth muscle and inhibiting of platelet aggregation[1].


[1] SL Dorris et al. PGI2 as a regulator of inflammatory diseases. Mediators Inflamm. 2012;2012:926968.

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Axon ID Name Description From price
2605 Selexipag Prodrug of MRE 269, a potent IP receptor (PGI2) agonist €90.00

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