The Prostacyclin (PGI₂) receptor , also termed the prostaglandin I2 receptor or just IP, is coupled to a guanosine nucleotide-binding α-stimulatory protein (Gαs). IP is found on a variety of cell types and exhibits broad physiological effects. PGI₂ regulates both the innate and adaptive immune systems and its effects are, for the most part, thought to be anti-inflammatory or immunosuppressive in nature. For a long time, PGI₂ has been understood to play a role in cardiovascular health, specifically having powerful vasodilatory effects via relaxation of smooth muscle and inhibiting of platelet aggregation[1].