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Ralinepag
- APD 811
Axon 2874
CAS:
1187856-49-0
Purity:
99%
- Soluble in DMSO
- MF: C23H26ClNO5
- MW: 431.91
Description
Ralinepag (APD811) is an orally bioavailable, non-prostanoid agonist of the prostacyclin IP receptor (PTGIR) with an EC50 value of 8.5 nM in a human IP receptor assay. It activates Gs–adenylyl cyclase signaling and increases intracellular cAMP.
Ralinepag shows good selectivity across prostanoid receptors, although selectivity over EP3 is more modest at approximately 30–50-fold. It produces vasodilatory and antiproliferative IP-receptor responses and is used in pulmonary vascular, smooth-muscle and pulmonary arterial hypertension models.
Key Features
- Potent non-prostanoid IP receptor agonist
- EC50: 8.5 nM
- Orally bioavailable
- Activates cAMP signaling
- Approximately 30–50-fold selective over EP3
Applications
- IP/PTGIR receptor pharmacology
- Prostacyclin signaling studies
- Vascular smooth-muscle assays
- Pulmonary vascular remodeling
- Pulmonary arterial hypertension models
More Information
| Parent CAS No. | 1187856-49-0 |
|---|---|
| Chemical Name | 2-(((1r,4r)-4-((Phenyl(p-tolyl)carbamoyloxy)methyl)cyclohexyl)methoxy) acetic acid |
| MFCD | N.A. |
| Short Description | IP agonist |
Ralinepag (APD811)
potent non-prostanoid IP receptor agonist
Ralinepag
APD811
APD 811
APD-811
Prostaglandins
PGI2 (IP)
non-prostanoid IP receptor
EP3 receptor
Agonist
cAMP signaling
prostanoid signaling
IP/PTGIR receptor pharmacology
Prostacyclin signaling studies
Vascular smooth-muscle assays
Pulmonary vascular remodeling
Pulmonary arterial hypertension models
vascular biology
hypertension
GPCR pharmacology
receptor selectivity
signal transduction
CAS 1187856-49-0
CAS 1187856-43-4
Axon Medchem
Axon 2874
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