TNKS

TNKS

Human tankyrases (TNKS; EC 2.4.2.30), or TRF1-interacting ankyrin-related ADP-ribose polymerases, are specific PARPs that enhance telomerase access to telomeres, and post-translationally modify multiple proteins involved in processes including maintenance of telomere length, sister telomere association, and trafficking of glut4-containing vesicles.. Tankyrase 1 and tankyrase 2 are poly(ADP-ribosyl)ases that are distinguishable from other members of the enzyme family by the structural features of the catalytic domain, and the presence of a sterile α-motif multimerization domain and an ankyrin repeat protein-interaction domain.

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More About TNKS

Human tankyrases (TNKS; EC 2.4.2.30), or TRF1-interacting ankyrin-related ADP-ribose polymerases, are specific PARPs that enhance telomerase access to telomeres, and post-translationally modify multiple proteins involved in processes including maintenance of telomere length, sister telomere association, and trafficking of glut4-containing vesicles.[1],[2]. Tankyrase 1 and tankyrase 2 are poly(ADP-ribosyl)ases that are distinguishable from other members of the enzyme family by the structural features of the catalytic domain, and the presence of a sterile α-motif multimerization domain and an ankyrin repeat protein-interaction domain[3].

[1] Y.J. Chiang et al. Tankyrase 1 and Tankyrase 2 Are Essential but Redundant for Mouse Embryonic Development. PLoSONE 2008, 3, e2639.
[2] H. Seimiya. The telomeric PARP, tankyrases, as targets for cancer therapy. Br. J. Cancer. 2006, 94, 341-345.
[3] L. Lehtiö et al. Tankyrases as drug targets. FEBS J. 2013, 280, 3576-3593.

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