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ME0328
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C19H19N3O2
- MW: 321.37
Description
ME0328 is a potent, cell-permeable, selective inhibitor of PARP3/ARTD3 (IC50 value of 0.9 μM).
More Information
| Parent CAS No. | 1445251-22-8 |
|---|---|
| Chemical Name | (S)-3-(4-Oxo-3,4-dihydroquinazolin-2-yl)-N-(1-phenylethyl)propanamide |
| SMILES | C1C=C2C(=O)NC(CCC(N[C@@H](C)C3C=CC=CC=3)=O)=NC2=CC=1 |&1:11,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)20-18(23)12-11-17-21-16-10-6-5-9-15(16)19(24)22-17/h2-10,13H,11-12H2,1H3,(H,20,23)(H,21,22,24)/t13-/m0/s1 |
| InChiKey | QIHBWVVVRYYYRO-ZDUSSCGKSA-N |
| CID | 135566764 |
| Short Description | PARP inhibitor |
References
- AE Lindgren et al. Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3. J Med Chem. 2013 Dec 12;56(23):9556-68.
- AE Lindgren et al. PARP inhibitor with selectivity toward ADP-ribosyltransferase ARTD3/PARP3. ACS Chem Biol. 2013 Aug 16;8(8):1698-703.
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