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RBN-2397
- Atamparib
- Optical Purity: Optically pure
- Soluble in DMSO and EtOH
- MF: C20H23F6N7O3
- MW: 523.43
Description
RBN-2397 is a potent, selective and orally active PARP7 inhibitor with an IC50 value of <3 nM. Moreover, RBN-2397 restores the type I interferon (IFN) response in tumor cells and induces antitumor immunity dependent on type I IFN and CD8 T cells.
More Information
| Parent CAS No. | 2381037-82-5 |
|---|---|
| Chemical Name | 5-((S)-1-Methyl-2-(3-oxo-3-(4-(5-(trifluoromethyl)-2-pyrimidinyl)-1-piperazinyl)propoxy)ethylamino)-4-(trifluoromethyl)-3(2H)-pyridazinone |
| SMILES | C1(=O)NN=CC(N[C@H](COCCC(=O)N2CCN(C3=NC=C(C(F)(F)F)C=N3)CC2)C)=C1C(F)(F)F |&1:7,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C20H23F6N7O3/c1-12(30-14-10-29-31-17(35)16(14)20(24,25)26)11-36-7-2-15(34)32-3-5-33(6-4-32)18-27-8-13(9-28-18)19(21,22)23/h8-10,12H,2-7,11H2,1H3,(H2,30,31,35)/t12-/m0/s1 |
| InChiKey | UQZCQKXJAXKZQH-LBPRGKRZSA-N |
| CID | 146047148 |
| Short Description | PARP7 inhibitor |
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