Nicotinamide phosphoribosyltransferase (NAMPT; EC, was originally discovered as the cytokine pre-B-cell colony-enhancing factor 1 (PBEF1) or visfatin, and has several suggested functions. It was found to be an important cofactor for stem cell factor– and interleukin (IL)-7-mediated B cell maturation. However, in 2002 the murine homologue of PBEF was found, and this proved to be an enzyme catalyzing the reaction between nicotinamide and 5-phosphoribosyl-1-pyrophosphate yielding nicotinamide mononucleotide (NMN), an intermediate in the biosynthesis of NAD/NADH: central molecules involved in energy metabolism, reductive biosynthesis, and antioxidation, histone deacetylation, cell death, and intracellular calcium release. This widened its potential biological activities. Interestingly, both extracellular (cytokine-like) and intracellular (enzymatic) functions seem to be responsible for its relevance in immunity, metabolism, and stress responses in both physiology and pathophysiology[1].

[1] T.B. Dahl, S. Holm , P. Aukrust, B. Halvorsen. Visfatin/NAMPT: a multifaceted molecule with diverse roles in physiology and pathophysiology. Annu. Rev. Nutr. 2012, 32, 229-243.

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Axon ID Name Description From price
1279 FK 866 NAMPT inhibitor; NAD biosysthesis inhibitor €90.00
1546 FK 866 hydrochloride NAMPT inhibitor €90.00
3557 KPT-9274 Orally bioavailable dual PAK4/NAMPT inhibitor €130.00
2602 P7C3 Proneurogenic and neuroprotective compound that activates NAMPT €105.00
2253 STF 118804 Highly specific, next-generation NAMPT inhibitor €120.00

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