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SBI-797812

Axon 3954
CAS:  2237268-08-3
Purity:  98%
  • Soluble in 0.1N HCl(aq) and DMSO
  • MF:  C19H22N4O4S
  • MW:  402.47

Description

SBI-797812 is an orally active NAMPT activator. SBI-797812 shifts the NAMPT reaction equilibrium towards NMN (Axon 3571) formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT at His247, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD+.

More Information

Parent CAS No. 2237268-08-3
Chemical Name 1-(4-(8-Oxa-3-azabicyclo[3.2.1]octan-3-ylsulfonyl)phenyl)-3-(pyridin-4-ylmethyl)urea
SMILES C1C=C(CNC(=O)NC2C=CC(S(=O)(=O)N3CC4CCC(C3)O4)=CC=2)C=CN=1
MFCD N.A.
InChi InChI=1S/C19H22N4O4S/c24-19(21-11-14-7-9-20-10-8-14)22-15-1-5-18(6-2-15)28(25,26)23-12-16-3-4-17(13-23)27-16/h1-2,5-10,16-17H,3-4,11-13H2,(H2,21,22,24)
InChiKey KTSOHNHLOLGQCY-UHFFFAOYSA-N
CID 135222620
Short Description NAMPT activator

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