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FK 866
- Daporinad - APO 866
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C24H29N3O2
- MW: 391.51
Description
FK 866 (Daporinad) is a highly specific nicotinamide phosphoribosyltransferase (NAMPT) inhibitor that blocks the NAD salvage biosynthesis pathway.
NAMPT controls cellular NAD+ production and is important for metabolic homeostasis, stress responses and cancer cell survival. FK 866 depletes NAD+ and is used to investigate metabolic vulnerability and apoptosis in tumor cell models.
Key Features
- Highly specific NAMPT inhibitor
- Blocks NAD+ salvage biosynthesis
- Induces metabolic stress and tumor cell apoptosis in models
- Reference compound for NAD metabolism research
Applications
- NAMPT enzyme inhibition assays
- NAD biosynthesis and salvage pathway studies
- Cancer metabolism and apoptosis research
- Metabolic stress response models
FK866 hydrochloride (Axon 1546) is also available.
More Information
| Parent CAS No. | 658084-64-1 |
|---|---|
| Chemical Name | (E)-N-[4-(1-Benzoyl-piperidin-4-yl)-butyl]-3-pyridin-3-yl-acrylamide |
| SMILES | C1CC(CCCCNC(=O)/C=C/C2C=NC=CC=2)CCN1C(=O)C1C=CC=CC=1 |
| MFCD | MFCD10565943 |
| InChi | InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+ |
| InChiKey | KPBNHDGDUADAGP-VAWYXSNFSA-N |
| CID | 6914657 |
| Short Description | NAMPT inhibitor |
References
- M. Hasmann and I. Schemainda, FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis, Cancer Res. 2003, 63, 7436-7442.
- A Pogrebniak et al. Chemopotentiating effects of a novel NAD biosynthesis inhibitor, FK866, in combination with antineoplastic agents. Eur. J. Med. Res. 2006, 11(8), 313-321.
- K Holen et al. The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor. Invest. New Drugs. 2008, 26(1), 45-51.
- List of publications using FK 866 (Axon 1279) purchased from Axon Medchem
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