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P7C3
- Soluble in DMSO
- MF: C21H18Br2N2O
- MW: 474.19
Description
P7C3 is an orally bioavailable, brain-penetrant nicotinamide phosphoribosyltransferase (NAMPT) activator that exhibits potent proneurogenic and neuroprotective properties. Rather than driving the proliferation of stem cells, P7C3 functions primarily by preventing programmed cell death (apoptosis) in newly postmitotic neurons.
NAMPT pharmacology represents a critical therapeutic target in Amyotrophic Lateral Sclerosis (ALS) research. P7C3 is an essential reference compound utilized to investigate NAMPT mechanisms and downstream NAD+ salvage pathways in biochemical and cellular assays.
Key Features
- NAMPT activator
- Boosts the rate-limiting step of the NAD⁺ salvage pathway
- Stabilizes mitochondrial membrane potential and energy homeostasis
- Prevents programmed cell death in newly formed neurons
Applications
- NAMPT pharmacology and target-validation studies
- NAMPT pathway and signaling assays
- Disease-model research related to ALS
- Compound profiling, assay development and lead-optimization support
More Information
| Parent CAS No. | 301353-96-8 |
|---|---|
| Chemical Name | 1-(3,6-dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol |
| SMILES | N1(CC(CNC2=CC=CC=C2)O)C2=C(C=C(Br)C=C2)C2=C1C=CC(Br)=C2 |
| MFCD | MFCD00572918 |
| InChi | InChI=1S/C21H18Br2N2O/c22-14-6-8-20-18(10-14)19-11-15(23)7-9-21(19)25(20)13-17(26)12-24-16-4-2-1-3-5-16/h1-11,17,24,26H,12-13H2 |
| InChiKey | FZHHRERIIVOATI-UHFFFAOYSA-N |
| CID | 2836187 |
| Short Description | NAMPT activator |
References
- G Wang et al. P7C3 neuroprotective chemicals function by activating the rate-limiting enzyme in NAD salvage. Cell. 2014 Sep 11;158(6):1324-34.
- AK Walker et al. The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis. Mol Psychiatry. 2015 Apr;20(4):500-8.
- S Bertini et al. Carbazole-containing arylcarboxamides as BACE1 inhibitors. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6657-61.
- AA Pieper et al. Discovery of a proneurogenic, neuroprotective chemical. Cell. 2010 Jul 9;142(1):39-51.
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