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AG 490
- Tyrphostin AG 490 - Tyrphostin B42
- Soluble in 0.1N NaOH(aq), DMSO and EtOH
- MF: C17H14N2O3
- MW: 294.3
Description
More Information
| Parent CAS No. | 133550-30-8 |
|---|---|
| Chemical Name | (E)-N-Benzyl-2-cyano-3-(3,4-dihydro xy-phenyl)-acrylamide |
| SMILES | C1(O)C=C(/C=C(C#N)/C(=O)NCC2C=CC=CC=2)C=CC=1O |
| MFCD | MFCD00209833 |
| InChi | InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+ |
| InChiKey | TUCIOBMMDDOEMM-RIYZIHGNSA-N |
| CID | 5328779 |
| Short Description | JAK2 Inhibitor |
References
- N Miyamoto et al. The JAK2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or Philadelphia chromosome. Leukemia 2001, 15, 1758-1768.
- O Sareila et al. JAK Inhibitors AG-490 and WHI-P154 Decrease IFN-γ-Induced iNOS Expression and NO Production in Macrophages. Mediators Inflamm. 2006,2006(2), 16161.
- N Meydan, et al. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor.Nature 1996, 379, 645-648.
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