KAT II

Kynurenic acid (KYNA) is formed enzymatically by the irreversible transamination of the pivotal kynurenine pathway metabolite l-kynurenine (l-KYN). This reaction is catalyzed by pyridoxal 5′-phosphate (PLP) dependent aminotransferases. At least four aminotransferases can utilize L-KYN as the amino donor of the transamination reaction in the mammalian brain. However, only one of them, kynurenine aminotransferase II (KAT II, E.C. 2.6.1.7), recognizes L-KYN unencumbered by abundant, competing amino acid substrates. This explains why KAT II accounts for the majority of cerebral KYNA synthesis in rat and human brain tissue[1],[2].


[1] F. Rossi et al.Crystal structure-based selective targeting of the pyridoxal 5'-phosphate dependent enzyme kynurenine aminotransferase II for cognitive enhancement. J. Med. Chem. 2010, 53, 5684-5689.
[2] L. Amori et al. On the relationship between the two branches of the kynurenine pathway in the rat brain in vivo. J. Neurochem. 2009, 109, 316-325.

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2237 BFF 122 Potent and selective inhibitor of kynurenine aminotransferase II €165.00

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