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1-NM-PP1
- Soluble in DMSO
- MF: C20H21N5
- MW: 331.41
Description
More Information
| Parent CAS No. | 221244-14-0 |
|---|---|
| Chemical Name | 1-tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine |
| SMILES | C1=NC(N)=C2C(CC3=C4C(C=CC=C4)=CC=C3)=NN(C(C)(C)C)C2=N1 |
| MFCD | MFCD17010191 |
| InChi | InChI=1S/C20H21N5/c1-20(2,3)25-19-17(18(21)22-12-23-19)16(24-25)11-14-9-6-8-13-7-4-5-10-15(13)14/h4-10,12H,11H2,1-3H3,(H2,21,22,23) |
| InChiKey | GDQXJQSQYMMKRA-UHFFFAOYSA-N |
| CID | 5154691 |
| Short Description | Src kinases inhibitor |
References
- AC Bishop et al. Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J. Am. Chem. Soc. 1999, 121 627-631 (1999).
- X. Chen et al. A chemical-genetic approach to studying neurotrophin signaling. Neuron. 2005, 46, 13-21.
- AC Bishop et al. A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 2000, 407 395-401.
- T Sugi et al. Use of the Kinase Inhibitor Analog 1NM-PP1 Reveals a Role for Toxoplasma gondii CDPK1 in the Invasion Step. Eukaryotic Cell 2010, 9(4), 667-670.
- X Wang et al. TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain. J. Neurosci. 2009, 29(17), 5508–5515.
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